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Chemistry 3410


Topics to be covered in Chemistry 3410 in Fall 2012

S. V. Pansare

Introduction

  • Primary versus secondary metabolites
  • Principal pathways

Carbohydrates

  • Simple monosaccharide types (and nomenclature)
  • Common disaccharides and polysaccharides
  • Anomeric effect
  • Reactions of monosaccharides and disaccharides
  • Selected protecting group chemistry

Amino acids, Peptides and Proteins

  • Structure, classification and properties of amino acids
  • Structure, classification and functions of proteins

Mechanisms of Coenzymes

  • Role of coenzymes in metabolism
  • Structures and reaction mechanisms of coenzymes

Polyketides

  • Biosynthesis from acetyl-CoA
  • Aldol-like and Claisen-like modes of cyclization
  • Anthraquinones and other examples

Lipids

  • Fatty acids
  • Prostaglandins and leukotrienes

Terpenes

  • Classification by "isoprene units"
  • Biosynthesis from acetate
  • Cyclizations of polyenes to selected mono, di, and sesquiterpenes
  • Biomimetic cyclizations
  • Steroids

Shikimic acid derivatives

  • Biosynthesis of shikimic and quinic acid
  • Biosynthesis of aromatic amino acids, cinnamic acids, lignans

Nucleic acids

  • Structural overview; RNA and DNA
  • Transcription, translation and protein synthesis
  • Chemical synthesis of nucleosides, nucleotides and polynucleotides