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Research highlights

The research group of Travis Fridgen is exploring the interactions of metal ions with biomolecules and the fundamental forces which give biomolecules their three-dimensional shape. Graduate and undergraduate research student's in Dr. Fridgen's group are using state-of-the-art instrumentation, combining ion-trapping mass spectrometry with tunable infrared lasers to spectroscopically probe the structures of these ions in the gas phase.

Recently (DOI: 10.1021/jp809993k) they have shown that solvating metal-ion bound DNA bases results in a huge structural change, promoting intramolecular hydrogen bonding.

Recent work by Peter Warburton and Ray Poirier has looked at defining both atoms and bonds in molecules by looking at the radial electron density. Continuing work in this direction will lead to new techniques in molecular modeling that are anticipated to significantly speed up many molecular modeling calculation types.