The mysterious grapefruit

For many years it was thought that nootkatone was responsible for the taste and smell of grapefruit. In fact the real contributor to grapefruit flavor is the compound below. We can detect 2x10-5 parts per billion of this compound, i.e. 10-4 mg. per tonne. Put another way, a few drops in a fair sized lake could be tasted. Evolution does some strange things!

Grapefruit should not be consumed with several commonly prescribed drugs - see this link


To be sung to the tune of "America the beautiful"

The carbonyl is polarized
The C is delta plus
The nucleophile will thus attack
The carbon nucleus
Addition makes an alcohol
(Of types there are but three)
It makes a bond, to correspond
From C to shining C

------- Prof. Frank Westheimer